The data of the experimental trial are given showing the influence of interleukin-1-beta (IL-1) receptors block using IL-1 receptors antagonist (IL-1ra) on kindling-induced seizures. IL-1 receptors block reveals anticonvulsant effect under conditions of picrotoxin-induced kindling. IL-1ra delays kindling development. The conclusion was done about the cytokines pathogenetic importance in epileptogenesis as well as about the chronic convulsive syndrome pathophysiologic mechanisms accenting on neural and immune systems pathological dysregulative integration development.
