In the in vitro experiments, it is shown that nanoparticles (NPs) of iron oxide (II, III) stabilized by ethylmethylhydroxypyridine succinate and low molecular weight polyvinylpirrolidon have hydrodynamic size of 14–70 nm and exhibit antimicrobial activity against the standard strains of gram-positive and gram-negative bacteria, and yeast fungi. This effect exceeds the action of non-stabilized NPs and may be associated with the presence of ethylmethylhydroxypyridine succinate in the formulation. It is suggesting that the stabilizing agent enhances the antimicrobial activity of iron oxide NPs by modifying of their interaction with the surface of microbial cell and changes in the production of active oxygen metabolites.
