Using as fyto gels, containing nanoagents of siver (Ag 5 and 10 mkm, 400 mcg/g) and gold (Au 5 nm, 500 mcg/g and 5 mcm, 400 mcg/g) on cilica application on the cheek mucosa randers anti-inflammatory and antidysbiotic action at experimental stomatitis, modelling on rats with the help of lipopolysacharide. Gel with aurum nanoparticles (5 nm) proves the expressed antidysbiotic activity. According to tested compounds safety one could recommend their clinical application.