The study is focused on developing of morphological criteria of biological tissue reactions to metal nanoparticles by detecting changes of tissues heteromorphism interacting with NPs. The study of heteromorphism tissue provides an integrated assessment of functional state of the tissue, allowing objectively evaluate the response of biological tissues in metal nanoparticles. Size-dependent effects of silver nanoparticles were identified, namely depending on the nanoparticles size recovery rate of basement membrane structure differs; the increase of mitotic index of the epidermal basal cells; changes of dermal fibroblasts’s heteromorphism, such as increasing of number of functionally active fibroblasts; and the number of collagen fibers of the dermis. Reactive changes of intradifferon heteromorphism of epidermal basal cells and the dermal fibroblasts was described using quantitative histological methods.
