It was studied the silver nanoparticles of 30 nm and medicines with thiopoetin group influence on skin wound healing in rats with diabetes mellitus, slow acetylation type and experimental suppression of antioxidant enzymes activity. The using of silver nanoparticles colloidal solution topically and medicines with thiopoetin group parenterally accelerates the experimental skin wound healing by restoring balance in thiol-disulphide system, increasing the functional activity of the epithelial cells of basal layer of epidermis. The effectiveness of experimental therapy increases in order: application of silver nanoparticles 30 nm colloidal solution; thiopoietins; silver nanoparticles + thiopoietins.
