The article highlights life and scientific activity of one of the famous pathophysiologicts of Ukraine — professor Anatoly Gozhenko, his 70-years anniversary was celebrated in February, 2018. The authors give information concerning his scientific achievements in the researches in such a major areas of pathophysiology as pathogenetic mechanisms of kidneys pathology, water-electrolyte metabolism disturbances and clinical pathophysiology introduction into the clinical and pedagogic processes. The special attention is given to his investigation of the following fundamental aspects of pathophysiology — both pathogenetic and sanogenetic mechanisms, disease definition and clinical pathophysiology.