The significant inter-ethnic differences concerning polymorphism of biotransformation genes affect the activities of numerous medicines. That is why the aim of current research was an investigation of polymorphism of cytochrome P-450 2E1 (CYP2E1) in healthy volunteers in Odessa region. So, it was studied a presence of mutation in 6th intron CYP2E1 with the help of DraI endonuclease and polymerase chain reaction.
According to CYP2Е1 genotype out of 112 donors 82,1 % carried homozygote wild type of gene *DD, others — 17,9 % had *CD genotype; carriers of *CС genotype were absent. There were no significant differences in CYP2Е1 genotype according to age, sex, blood group. The polymorphism of CYP2E1 genotype on south of Ukraine was close with results from European countries, including Russia and Turkey and varied from data of South-East Asia (Malaysia, Chine) and USA.