The article traces the life and work of the famous hygienist Gregory Vitalievitch Khlopin (1863–1929), who was the representative of the scientific school of Moscow professor-hygienist Fyodor Fyodorovich Erisman (1842–1915) and the founder of his own scientific school. New archival materials were presented. The period of his work in Odessa (1903–1904) is reported in more details.