Under condition of acute experiment on Wistar rats it was established that it is noticed glycosaminoglycanes metabolism deterioration, which manifests itself in the decreasing of uronic acids in the duodenal wall by 30.8%, induced via immobilization and painful electrical stimulations. When stress was induced after reserpine administration (2.5 mg/kg, i. p. during 3 days) the level of uronic acids was reduced by 47.3%, content of hexosamines was reduced by 23.9% while both oxyproline level and activity of β-galactosydase increased by 32.7% and by 37.5% correspondently. Combined usage of L-deprenyl and pentoxyphillin in dosages which were non-effective when used separatively (0.5 and 50.0 mg/kg, i. p. correspondently) caused stress-protection with respect to all indices which were under investigation.
