The state of functional reactions and nonspecific resistance in 12–14-year old children which have maxillodental anomalies before the beginning of orthodontic treatment was determined in the study. There were determined the state of the hygiene of the oral cavity and periodontal tissue; teeth caries intensity; pH and the confidence interval of oral liquid pH (ΔрН); the state of buccal epithelium; it is carried out spectrocolorimetrical exam of teeth and periodontal tissue, ultrasonic densitometry; echo-osteometry of the upper and law jaw; biochemical studies of oral liquid.