The aim of the work was to define the epileptic activity dynamics under conditions of super high electromagnetic waves frequency (SHEM) radiation (7.1 mm, 0.1 J/cm2) upon focal epileptic activity, which was penicillin-induced (10.000 IU/ml) in frontal zones of brain cortex in myorelaxed and artificially ventilated rats under acute experimental condition. It was established that preliminarily performed hypogeomagnetic period (3.0 hrs) with the inductivity of geomagnetic field reduction not less than 100 times, caused the intensification of antiepileptic effects of SHEM (15.0 min of exposition). It was pronounced in the form of falling down of foci power and significant reduction of the life-span of foci — up to (115.3±13.4) min, which was both significant when compared with the separate effects of hypogeomagnetic influence (187.3±16.4) min and SHEM (15.0 min of exposition) effect ((164.2±12.5) min) (P<0.05).