ROLE OF GENETIC FACTORS IN REGULATION OF LABOR ACTIVITY

The genetic constituent of labor process remains unclear up to present. The aim of this research was a study of causal relationship between expression of genes in the placentas of late terms of pregnancy and process of labor for subsequent determination of role of genetic factors, in particular, profile of genetic expression in the placenta, in prognostication of obstetric pathology. Comparison of genetic expression profile in placentas after conservative and operative delivery allowed to set that expression of none of these genes was not changed truthworthy, i. e. more, than 2.5 fold. The obtained data allow to conclude that the process of labor does substantially affect expression of genes in the placenta corresponding to the term of labor, which allows to apply research of genetic expression profile in the placenta in order to reveal new nosotropic mechanisms and biomarkers of obstetric pathology.