The article of a famous scientist Denis N. Wheatley is dedicated to an important clinical problem — increasing of efficiency of malignant neoplasms combined treatment. The author touches the problem analysing the present ideas about a unique nature of malignant process pathomorphosis and the absense of the only correct approach to treatment for all the types of tumor. From the author’s point of view the treatment process consists not in increase of efficacy of separate treatment modes, but in search for a possibility to take control over the tumor process. The article presents both the own data of long term researches, but experimental ones. Arginin usage in combined therapy allowed the author to decrease significantly the doses of applied toxic agents including X-ray therapy and correspondingly improve the prognosis for different kinds of tumors, disseminated ones as well.