There were reviewed 2005–2008 publications for the scope of the perspective directions of studies on the molecular-genetic determinants of multifactorial diseases. It was stated that inspite of the intensive environmental pollution the investigations of ecogenetic mechanisms of multifactorial diseases development are out of the mainstream of scientific researches. The complex assessment of the role of genetic polymorphism of xenobiotic metabolising enzymes for the determination of non-infectious diseases is not conducted in Ukraine. Thus there is expediently to study the molecular-genetic determinant of population health in the Ukrainian region with the different level of environmental safety.
