Information on experimental research of hepatoproteсtive activity of oxyethylidendiphosphonate germanates with different bioligands — MIGU-4 (with nicotinic acid), MIGU-5 (with nicotinamid) is resulted in the article. The LD50 doses of toxins (galactosamine, carbon tetrachloride) are established. Morphohistological research confirmed, that introduction of the toxins in these doses resulted in development of acute hepatitis. Thus, galactosamine is less toxic than carbon tetrachloride. Introduction of the explored biologically active substances increases the survivability of animals depending on the type of hepatotoxins, conditions of administration of the compounds and dose mode. Introduction of the compounds 3 h before the application of toxins with a subsequent 7-day course is the most effective. The 1/20 LD50 dose is the most optimal. However, these finding need subsequent research of hepatoproteсtive properties of these substances. On the basis of study of MIGU-4 and MIGU-5 influence on animals survivability it is not possible to do the conclusion about advantages of one compound over another one.
