Authors outline their own experimental data as well as other experimental results concerning the problem of possible interrelation between epilepsy and brain inflammation. It was shown an increased production of different molecules including proinflammatory cytokines, representatives of which are tumor necrosis factor-alpha and interleukine-1-beta, starting simultaneously with the experimental seizure syndrome. Proinflammatory cytokines levels increase not only in the brain but also in plasma and cerebro-spinal fluid during the chronic seizures that are in favour of host response generalization due to cytokines involvement. Experimental results are proved by the numerous clinical data. The authors concluded about the numerous experimental and clinical data proved the inflammation importance in the epilepsy pathophysiological mechanisms.
