In the article one can see data regarding experimental investigation of vasodilating activity of the derivatives of germanium diphosphonates with bioligands — MIGU-4 (with nicotinic acid), MIGU-5 (with nicotinamide), and MIGU-6 (with magnesium). It was found that all compounds had dilatory effect at the model of isolated thorax aorta of rats, but MIGU-6 had the most significant statistically-proved one. At the model of non-lesional endothelium, MIGU-6 also led to the decrease of contraction amplitude. After de-endothelization of the vessels sample effect of MIGU-6 wasn’t registered that suggests endothelium-dependent origin of this effect.
