PATHOGENETIC BACKGROUND OF REGULATIVE PEPTIDES USE IN EXPERIMENTAL CHRONIC STRESS COMPLEX THERAPY

Dalargin antistress efficacy was investigated in rats in condition of chronic stress modelling. Chronic stress was shown to increase the rats’ aggressive behaviour as well as stress-responsible organs weight decreasing and lymphopoetic organs weight increasing. This condition was followed by the suprarenal glands cortical and cerebral layers width increasing also. Dalargin using in rats with chronic stress modelling resulted in the mentioned effects normalization. The data obtained are discussed from the point of view of dalargin recommendations to be involved into the stress-induced components of the somatic diseases complex pharmacological correction.