THE PATHOGENEGICAL BASIS OF THE PROGREDIENT COURSE OF MILD REPEATED MILD CRANIOCEREBRAL INJURY

In an experiment on 90 white rats there were studied pathomorphological changes after a repeated mild CCI. The experiment revealed that a repeated TBI is characterized by steady pathomorphological changes like enlargement of degeneratively changed neurons, the “neuron/glia” ratio decrease, active mitochondria area reduction, and decrease in chromatin in karyoplasm. The changes were triggered by diffuse axonal damage during acute brain injury and by further microcirculation disruption. The most steady changes were observed in the hippocampal area and hypothalamus on the injured side.

Cytokine levels (pro- IF-γ, TNF-α and anti-inflammatory KEL-10) in 17 patients with repeated light TBI with progradient and regradient course of traumatic disease at the intermediate stage were studied. The information content of cytokine levels can be assessed by studying a misbalance between pro- and anti-inflammatory cytokines and determining their correlation index. TBI in the progradient course is characterized by Th2 immune response type prevalence, while in regradient course — by Th1 immune response type prevalence.