COMPARATIVE PHARMACOLOGICAL ACTIVITY OF NEW BIOLOGICALLY ACTIVE SUBSTANCES — DERIVATIVES OF DIPHOSPHONATE ACIDS

The series of experiments, allowing in a comparative aspect to estimate hepatoproteсtive activity both — of a new complex compound MIGU-6 (magnesium-oxyethylidendiphosphonate germanates) and components of its synthesis and other BAS of this class (nicotinic acid and nicotinamide- oxyethylidendiphosphonate germanates) such as oxyethylydendiphosphonate (ethydronic) acid, elements of germanium and magnesium, nicotine acid, nicotinamide, are resulted in the article. The conducted research on model of galactosamine hepatitis in rats showed that MIGU-6 has the enough expressed hepatoprotective action. Although prophylactic-cure introduction to the animals of some components of new BAS (ethydronic acid, germanium) exhibited some hepatoprotective effect, it proved that the molecule of complex compound of oxyethylidendiphosphonate germanates, not components of its synthesis, determines its pharmacological activity.