PATHOGENETIC BASIS FOR THE THERAPY OF EXPERIMENTAL BRAIN TRAUMA

Literature data have been analyzed by authors, which are in favor for the precipitance of trauma — released brain functions deterioration as a result of interrelationships of activity of both endogenous systems of excitatory amino acids and dopaminergic system, on the one side, with the immunological mechanisms, on the other side. The beneficial effects in posttraumatic period of combined usage of dopaminomimetics with pharmacons, which are able to reduce the activity of endogenous proinflammatory cytokine system is stressed.