We investigated the mechanisms of new MIGU-4, -5, -6 compounds influence on the processes of training, memory, extraction of the experience by the conditional reflex formation in the tests of active avoidance in the present work. Also we studied effects of these compounds on resistance to conditional reflex dying away in the test of the negative confirmation with use M-cholinolithic — atropine. It was shown that systemic administration of MIGU caused nootropic action with improvement of the processes of training, conditional reflex formation in the tests of active avoidance. MIGU-6 induced a dose-dependent impairment of memory in the active avoidence test. Atropine both induced the impairment of memory and potentiated the MIGU-6 amnestic effect.
