Antiseizure effects of cerebellum is mediated via peroxisomal proliferator-activated γ-receptors (PPAR-γ)

Godlevsky, L. S.; Pervak, M. P.; Lyashenko, A. V.; Bidnyuk, K. A.

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dc.contributor.author	Godlevsky, L. S.	en
dc.contributor.author	Pervak, M. P.	en
dc.contributor.author	Lyashenko, A. V.	en
dc.contributor.author	Bidnyuk, K. A.	en
dc.date.accessioned	2022-12-09T11:06:02Z
dc.date.available	2022-12-09T11:06:02Z
dc.date.issued	2021
dc.identifier.citation	Godlevsky L. S. , Pervak M. P., Lyashenko A. V., Bidnyuk K. A. Antiseizure effects of cerebellum is mediated via peroxisomal proliferator-activated γ-receptors (PPAR-γ) // Pathological physiology – health care of Ukraine (dedicated to the 120th anniversary of the Odessa pathophysiological school): VIII National congress pathophysiologists Ukraine, 6–8 th October 2021, Odessa. P. 7–8.	en
dc.identifier.uri	https://repo.odmu.edu.ua:443/xmlui/handle/123456789/11721
dc.description.abstract	Earlier on the model of pentylenetetrazol (PTZ) – induced kindling it was shown that blockade of PPARγ with bisphenol A diglycidyl ether (2,2’-[(1-methylethylidene) bis(4,1- phenyleneoxymethylene)] bis-oxirane (BADGE) abolished the antiseizure effects of cerebellar transcranial direct current stimulation (tDCS) performed with the cathode (Godlevsky L.et al., 2017). Furthermore, PPARγ agonist pioglitazone caused the suppression of epileptiform activity on both acute and chronic models of epilepsy. Meanwhile, combined effects of cerebellar tDCS and PPARγ agonists have not been investigated yet. Objective: The investigation aimed to determine characteristics of seizure dynamic in rats with PTZ-induced kindling under conditions of cerebellar tDCS performed after pioglitazone administration.	en
dc.language.iso	en	en
dc.subject	antiseizure effects of cerebellum	en
dc.subject	peroxisomal proliferator-activated γ-receptors (PPAR-γ)	en
dc.subject	PTZ-induced kindling	en
dc.subject	cerebellar tDCS	en
dc.title	Antiseizure effects of cerebellum is mediated via peroxisomal proliferator-activated γ-receptors (PPAR-γ)	en
dc.title.alternative	Антисудомний ефект мозочку опосередковується через перексисомальний проліфератор γ-рецепторів (PPAR-γ)	ru
dc.type	Article	en