Synergy of antiseizure and anxiolytic action of rapamycin and histamine H₃ inverse agonist pitolisant on the PTZ-kindled seizures

Abstract

Neuroinflammatory contribution is principal for developing chronic epileptic seizures. The work aimed to investigate chronic seizures and anxious behavior in pentylenetetrazole (PTZ)-kindled rats under combined treatment with the histamine H₃ blocker pitolisant and mTOR blocker rapamycin.