Applying bioactive compounds of Pseudomonas SPP. For medicine substance development

Abstract

Infectious diseases are still a worldwide important problem. This fact has led to the characterization of new biomarkers that would allow an early, fast and reliable diagnostic and targeted therapy. In this context, Pseudomonas aeruginosa can be considered one of the most threatening pathogens since it causes a wide range of infections. Antibiotic treatment is not trivial given the incidence of resistance processes and the fewer new antibiotics that are placed on the market. With this scenario, relevant quorum sensing (QS) molecules that regulate the secretion of virulence factors and biofilm formation can play an important role in diagnostic and therapeutic issues. P. aeruginosa is an opportunistic nosocomial human pathogen, which causes a broad spectrum of acute and chronic infections such as bloodstream infections in intensive care units, burn and chronic dermal wound infections, surgical site infections, hospital-acquired pneumonia and respiratory and urinary tract infections.