Вплив грибів роду CANDIDA на перебіг хронічного простатиту у хворих на доброякісну гіперплазію передміхурової залози

Abstract

Верификация кандидозного поражения предстательной железы значительно затруднена вследствие различных факторов. В работе приведены данные морфологических исследований ткани простаты, по результатам которых сделаны выводы относительно влияния грибов рода Candida на особенности течения хронического простатита и доброкачественной гиперплазии предстательной железы.

About 18% healthy adult men are carriers of yeast fungi, but the Candida infection of prostate is rarely detected, which is associated with the fungus static action of prostate’s secretion and considerable difficulties in diagnosis of candidosis. The objective of the work is to define Candida fungi influence on the chronic prostatitis course in patients suffering from benign prostate hyperplasia (BPH). Methods. The object of research were 40 patients suffering from BPH, who were verified urogenital candidosis with the usage of bacteriologic, bacterioscopic and morphologic methods of investigation. Morphological research of the prostate tissue revealed visceral candidosis in 35.0% patients operated on BPH. The morphological picture of prostate tissue in BPH patients, associated with Candida fungi, had a number of features both on the side of fungi and prostate tissue. The distinctive feature of prostate tissue visceral candidosis is that almost all the elements of the causative agent are localized in the muscular layer, which explains the absence of clinical signs of this pathology. The fall of activity of fungi protective mechanisms agains a background of hypoxy at the area of ischemic tissue, due to the inflammatory edema and presence of hyperplasia nodules, exclude a possibility of acute condition. Taking into account the new necrobiosis foci detecting, one should consider that they can transit into fibrosis in future with sclerosing and calcification, which results in formation of the focus of persistent Candida-carriering, which causes visceral candisosis relapse and BPH signs. Chronic prostatitis associated with Candida fungi in BPH patients has no special clinical signs and can be hardly detected with non-invasive methods. Presence of Candida fungi in prostate tissue of BPH patients accelerates the sclerosing processes, which makes an effects on chronic prostatitis course and benign hyperplasia.