Contribution of peroxide processes to pathogenetic mechanisms of experimental liver cirrhosis

Abstract

The results of a series of experimental trials using rats with toxic liver cirrhosis are given. After 12 hours, and in 1, 3, 5 and 7 days after the pathological condition simulation, blood erythrocytes in animals as well as homogenates of liver parenchyma and pancreatic lipid peroxidation were determined by calculation of concentration of lipoperoxidation intermediates and the activity of antioxidant enzymes. The findings suggest that the course of experimental cirrhosis is accompanied by sharp intensification of lipid peroxidation and associated inhibition of the enzymatic activity and non-enzymatic antioxidant protection units, as noted in 5 days with a maximum severity on the day 3. There was shown the involvement of erythrocytes in mediating the pathological process, as well as the liver parenchyma and pancreas. The authors conclude that the complex pathogenetic therapy of liver cirrhosis should include the administration of preparations with expressed antioxidant properties.