Determination of physical and chemical properties of blood plasma and ascetic fluid in patients with liver cirrhosis

Abstract

With the aim of individual treatment strategy selection authors studied proteins content as well as both blood plasma and ascites chemical properties characteristics in patients with liver cirrhosis at different stages of its intensity. 262 patients with liver cirrhosis were divided into 4 groups according to diagnostic examination results which revealed different severity of the pathological process in the liver parenchyma. Proteins level, total bilirubin content, the average mass molecules, the residual nitrogen, urea, creatinine, ALT, AST, alkaline phosphatase, cholesterol and lecithin concentrations were determined in blood plasma and ascites of patients with liver cirrhosis. The data obtained reveal protein homeostasis disturbance, atherogenic lipoproteins levels increase that induce hepatocytes membrane structure failure in patients with liver cirrhosis at all stages. Ascites detected components correlated with the liver parenchyma degree of functional activity disturbances. The authors conclude that homeostasis disorders established in patients with liver cirrhosis complicated by ascites should be taken into account in cases of surgical tactics performing out.