Proteolytic system activity dysfunction in case of experimental liver cirrhosis

Abstract

Experimental data presented are devoted to influence of the alpha-lipoic acid and tivortin on activity of proteolytic enzymes in conditions of experimental liver cirrhosis in rats. Experimental model of CCl4-induced liver cirrhosis was shown to be accompanied by the proteolysis system activation. Both pharmacological compounds were shown to reveal the similar normalising effect resulting in the normalisation of proteolytic activity starting 6 hours after the disease induction. The therapeutic efficiency of the alpha-lipoic acid is higher than that of tivortin in case of their single administration in the modelled condition. The data obtained showed the pathogenetic importance of the proteolytic system activation in case of the experimental liver cirrhosis. The data is also an experimental background for prospects of using the tested pharmacons in the pathogenetically oriented complex correction of liver functioning in clinical conditions.