Proteolytic system activity dysfunction in case of experimental liver cirrhosis

Dzygal, A.; Grubnik, Yu.

dc.contributor.author	Dzygal, A.	en
dc.contributor.author	Grubnik, Yu.	en
dc.date.accessioned	2020-10-20T05:37:26Z
dc.date.available	2020-10-20T05:37:26Z
dc.date.issued	2016
dc.identifier.citation	Dzygal A., Grubnik Yu. Proteolytic system activity dysfunction in case of experimental liver cirrhosis // GISAP: medical science, pharmacology. 2016. N 11. P. 26–29.	en
dc.identifier.uri	https://repo.odmu.edu.ua:443/xmlui/handle/123456789/8093
dc.description.abstract	Experimental data presented are devoted to influence of the alpha-lipoic acid and tivortin on activity of proteolytic enzymes in conditions of experimental liver cirrhosis in rats. Experimental model of CCl4-induced liver cirrhosis was shown to be accompanied by the proteolysis system activation. Both pharmacological compounds were shown to reveal the similar normalising effect resulting in the normalisation of proteolytic activity starting 6 hours after the disease induction. The therapeutic efficiency of the alpha-lipoic acid is higher than that of tivortin in case of their single administration in the modelled condition. The data obtained showed the pathogenetic importance of the proteolytic system activation in case of the experimental liver cirrhosis. The data is also an experimental background for prospects of using the tested pharmacons in the pathogenetically oriented complex correction of liver functioning in clinical conditions.	en
dc.language.iso	en	en
dc.subject	proteolysis	en
dc.subject	liver cirrhosis	en
dc.subject	alpha-lipoic acid	en
dc.subject	tivortin	en
dc.subject	pathogenetic mechanisms	en
dc.subject	pharmacological treatment	en
dc.subject	pathogenetically oriented complex correction	en
dc.title	Proteolytic system activity dysfunction in case of experimental liver cirrhosis	en
dc.type	Article	en