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Recent submissions

Видання іноземною мовою. Кафедра симуляційних медичних технологій: Recent submissions

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On metabolic deteriorations in pentylenetetrazol (PTZ) kindled rats revealed with glucose tolerance test and liver histology

Pastukhov, O. O.; Pervak, M. P.; Smirnov, I. V.; Bukreeva, N. I.; Litvinenko, M. V.; Godlevsky, L. S. (2024)

Manifestations of metabolic syndrome (MS) man‑ ifestations in chronic epilepsy models were in the scope of the investigation. Kindling was induced by daily injections of PTZ at a dose of 35 mg/kg i.p. for three weeks. ...
Cerebellar transcranial direct current stimulation (tDCS) and pitolisant prevented behavioral and neuroinflammatory disturbances in pentylenetetrazol (PTZ) kidnling

Pervak, M. P.; Yehorenko, O. S.; Onuphrienko, O. V.; Varava, S. V.; Litvinenko, M. V.; Godlevsky, L. S. (2024)

The work aimed to investigate behavioral mani‑festations in PTZ‑kindled rats under combined treat‑ment with the histamine H3 receptor inverse agonist pitolisant and mTOR blocker rapamycin. Kindling was produced in Wistar ...
Role of intensity of electrical stimulation (ES) in the cerebellar antiepileptic effectiveness under conditions of diazepam administration

Godlevsky, L.; Pervak, M.; Poshyvak, O. (2021)

ES of brain structures combined with antiepileptic drugs is a promising approach for better pharmacological control of resistant seizures. Aims. To investigate the dynamic of penicillin-induced foci in cats' brain cortex ...
Role of peroxisomal proliferator-activated Y-receptors in analgesia induced with cerebellar stimulations in kindled rats

Pervak, М.; Poshyvak, O.; Son, H.; Prybolovets, K.; Latypov, K.; Godlevsky, L. (2021)

Background. Antiepileptic effects induced with cerebellar transcranial direct current stimulation (TDCS), and the role of peroxisomal proliferator-activated γ-receptors (PPARγ) in its development have been shown (Godlevsky, ...
Pioglitazone intensifies antiseizure effects of cerebellar transcranial direct current stimulation (TDCS) upon kindled seizures

Pervak, M.; Godlevsky, L.; Poshyvak, O.; Latypov, K.; Prybolovets, K. (2021)

Background and aims The suppression of epileptic activity follows TDCS. It was shown that blocking peroxisomal proliferator-activated γ-receptors (PPARγ) with BADGE, (100 mg/kg, i.p.) prevented antiseizure effects caused ...
Neurodegeneration and neoangiogenesis in the cerebellar cortex in pentylenetetrazol (PTZ) - kindled rats treated with axitinib and rapamycin

Godlevsky, L.; Pervak, M.; Poshyvak, O.; Latypov, K.; Prybolovets, K. (2021)

Morphological changes induced in pentylenetetrazol (PTZ)- kindled rats create the basis for the resistance of chronic brain epileptization. Cerebellar contribution to kindling seizures development was shown (Godlevsky ...
Neuronal loss and angiogenesis are suppressed with cerebellar transcranial direct current stimulation in pentyelenetetrazol kindled brain

Pervak, M.; Bidnyuk, V. K.; Varava, S. V.; Al-Nadawi, N.; Latypov, K. A.; Godlevsky, L. S. (2023)

Loss of neurons and angiogenesis underlay pathogenesis of chronic epilepsy. The aim of the work was to investigate the neuronal and microvascular density of the frontal cortex, ventral hippocampus, and retina of ...
Daytime sleep-wakefulness cycle disturbances are effectively reversed with pitolisant in pentylenetetrazol-kindled rats

Yehorenko, O. S.; Pervak, M.; Latypov, K. A.; Prybolovets, K.; Shcheglov, I. A.; Godlevsky, L. S. (2023)

Chronic brain eptisation induces sleep-wakefulness (SW) disturbances. The work aimed to investigate SW cycle in pentylenetetrazole (PTZ)- kindled rats under combined treatment with the histamine H₃ inverse agonist ...
Synergy of antiseizure and anxiolytic action of rapamycin and histamine H₃ inverse agonist pitolisant on the PTZ-kindled seizures

Poshyvak, O. B.; Pinyazhko, O. R.; Pervak, M.; Yehorenko, O. S.; Prybolovets, K.; Godlevsky, L. S. (2023)

Neuroinflammatory contribution is principal for developing chronic epileptic seizures. The work aimed to investigate chronic seizures and anxious behavior in pentylenetetrazole (PTZ)-kindled rats under combined treatment ...
Comparative effectiveness of niacin-oxietilyden-di-phosphonste germanat (MIGU-4) and diazepam upon neuronal loss in the retina of rats with pentylenetetrazol (PTZ)

Al-Nadawi, N.; Pervak, M.; Prybolovets, K.; Arabadzhi, D. R.; Apollonov, D. R. (2023)

Epilepsy is accompanied by neuronal loss, which is observed in the retina as well. The work aimed to study the density of neurons in retina layers of rats with pentylenetetrazol (PTZ)-kindled seizures and compare ...
Functional links in the brain cortex of kindled rats evaluated at different stages of kindling seizures precipitation

Pervak, M. P.; Godlevsky, L. S. (2023)

The work investigated the relationships between brain structures established in different periods of pentylenetetrazol (PTZ)-induced kindled seizure precipitation. As structures for investigations, the cortical ones of ...
On the role of ATP-dependent potassium channel Kir6.2 and hypoxiainduced factor-1α in the pentylenetetrazole kindling pathogenesis

Doganyigit, Z.; Okan, A.; Akyuz, E.; Poshyvak, O. B.; Pervak, M. P.; Yehorenko, O. S.; Hathal, S. N. A.; Доганьїгіт, З.; Окан, А.; Акьюз, Е.; Пошивак, О. Б.; Первак, М. П.; Єгоренко, О. С.; Хатал, C. Н. А. (2022)

The purpose of the study was the immunohistochemical examination of the expression of the ATP-sensitive potassium (K+) channel Kir6.2 and hypoxia-inducible factor 1α in the dorsal hippocampus in kindled rats. Kindling was ...
The correlation of overweight and threatened miscarriage of pregnancy in South Ukrainian women

Nadvorna, O.; Krugliachenko, O.; Petrovskiy, Yu.; Rudenko, I. (2018)

According to WHO report 53,5% of adults in Ukraine are overweight and 21,3% are obese. In addition, MOH of Ukraine reports STIs (Sexually transmitted infections) as a national problem of Ukrainian healthcare. The aim of ...
Simulated patient: a textbook

Marichereda V. G.; Rogachevskyi, O. P.; Pervak, M. P.; Yehorenko, O. S.; Belozertseva-Baranova, Yu. Ye.; Onyshchenko, V. I.; Karakonstantyn, D. F.; Dobrovolskyi, A. L. (2023)

The textbook covers the basic principles of organizing the educational process involving standardized patients. For heads of secondary and higher medical educational institutions, teaching staff, and working groups on the ...
Modernization of theoretical and practical aspects of the development of higher medical education in Ukraine

Holomb, L.; Rogachevskyi, O.; Karbovanets, O.; Senkevych, O.; Vivsyannuk, V. (2022)

The coronavirus pandemic has become a challenge for national health care systems, a global problem that has accelerated the processes of reforming medical education in many countries. The purpose of the article is to ...
Theoretical foundations of competitiveness management of health care institutions

Safonov, Yu.; Borshch, V.; Rogachevskyi, O. (2022)

Increasing the competitiveness of health care institutions is an urgent issue for health care in the new funding environment. The purpose of this work is to analyze the existing tools for ...
Immunohistochemical neuroinflammatory markers in the hippocampus of PTZ-kindled rats under conditions of rapamycin and axitinib treatment

Poshyvak, O.; Pinyazhko, O.; Godlevsky, L.; Pervak, M.; Yehorenko, O.; Doganyigit, Z.; Okan, A.; Akyuz, E.; Hathal, N. A.; Liashenko, A. (2023)

The aim of the study is to determine the level of HIF-1α, TNF-α, and NF-kB in the hippocampus of kindled rats treated with rapamycin and axitinib. Materials and methods. Kindling was produced in 29 rats by administration ...
Antiseizure effects of cerebellum is mediated via peroxisomal proliferator-activated γ-receptors (PPAR-γ)

Godlevsky, L. S.; Pervak, M. P.; Lyashenko, A. V.; Bidnyuk, K. A. (2021)

Earlier on the model of pentylenetetrazol (PTZ) – induced kindling it was shown that blockade of PPARγ with bisphenol A diglycidyl ether (2,2’-[(1-methylethylidene) bis(4,1- phenyleneoxymethylene)] bis-oxirane (BADGE) ...
Emergency conditions as simulation medical scenarios for applicants of education

Pervak, M. P.; Onyshchenko, V. I.; Yehorenko, O. S.; Karakonstantyn, D. F. (2021)

Emergency conditions are very life-threatening situations and require fast actions and immediate intervention from medical stuff. For young doctors without extensive experience in the treatment of these important diseases, ...
Prevention of formalin-induced nociceptive behaviors caused by PPAR-gamma activation strengthened with cerebellar transcranial direct current stimulation

Poshyvak, O. B.; Pinyazhko, O. R.; Hathal, Suliman N A,; Pervak, M. P.; Ehorenko, O. S.; Liashenko, A. V. (2021)

The investigation was performed on 55 male Wistar rats. The pain behaviors were induced through the formalin (2.5%) subcutaneous administration into the plantar surface of the right hind paw. Pain score value was determined ...

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