The results of immunohistochemical studies of both progesterone-synthetic and apoptotic processes inside the structural elements of the main source of intra-abdominal bleeding of ovarian etiology, the corpus luteum and its cysts are presented. The peculiarities propapoptotic transmembrane protein — CD95 expression within stromal and epithelial cells and capillary cells were studied in the extirpated throughout the operative interventions macrosamples. Progesterone-synthetic activity was determinned by counting the relative number of progesterone progenitor cells in the corpus luteum epithelial component. A statistically significant negative relationship between the number of progesterone progenitor cells and CD95 expression level was established. A significantly high level of CD95 apoptosis factor expression and a relatively low amount of progesterone-synthesizing granulose-teuclate-luteocytes in the cystic-altered corpus luteum indicate that ovarian apoplexy in patients with minimal and moderate hemoperitoneum develops mainly at the stage of corpus luteum regression and occurs on background of chronic failure of the menstrual cycle luteal phase.
Otherwise, in patients where ovarian apoplexy accompanies by a high volume of intraabdominal hemorrhage the big level of progesterone-producing cells and low apoptotic activity indicate that disease develops in these patients at the pick of corpus luteum functional activity isn’t characterized by the lutheinic phase insufficiency syndrome.