One of the main causes and an important risk factor for acute stroke (AS) is diabetes mellitus (DM), which aggravates the course of a stroke, increases the risk of complications and fatal outcome. Neuroprotectors are now widely used to reduce neurological deficits and improve the results of AS treatment. Aim: to investigate the effectiveness of citicoline and magnesium sulfate as a combined neuroprotective therapy in patients with acute stroke with concomitant diabetes mellitus.
The comprehensive clinical-neurological and laboratory examination was carried out of 346 patients (171 women and 175 men) who suffered acute ischemic stroke with and without such carbohydrate metabolic disorders (main groups). In the main groups of patients, as a neuroprotective agent, citicoline 1000 mg 1 time per day was administered and a solution of magnesium sulfate 25% 30 ml per day in 2–3 injections. To determine the effectiveness of the developed scheme of intensive care, a separate group (36 patients — 16 women and 20 men) was selected, in which treatment was carried out according to the traditional approach (control group). In the control group various preparations with the declared manufacturer neuroprotective action (except for citicoline and magnesium sulfate) were used.
The combination of citicoline with magnesium sulfate was reliably effective in treating patients with AS against the background of concomitant diabetes. In patients without diabetes, the effectiveness of this combination was lower, and in the group of patients who received the traditional treatment of significant differences in the dynamics of clinical and laboratory parameters was not found.