The risk of perinatal morbidity and mortality for pregnant women with hypertension depends on the severity of preeclampsia, the age of pregnant women, the level of hyperhomocysteinemia, the incidence of delayed fetal development, the number of premature births and the increase of the rate of spontaneous oxidative modification of the protein.
The purpose of the research was to identify and investigate the risk factors for mortality of newborn from pregnant women with hypertensive disoders.
Materials and methods of research. It was studied the process of pregnancy, the condition of fetuses and newborns from 120 pregnant women with hypertensive disorders. The primary group consisted from pregnant women with moderate preeclampsia (n=30), who reported neonatal mortality (n=1). The comparison group consisted of pregnant women with chronic hypertension-grade I and mild preeclampsia, whose children survived after birth (n=60), control group was healthy pregnant women (n=30).
Results of the research and their discussion. It was found that in the researched groups there was a significant difference in maternal age (p=0.019), terms of gestation at birth (p<0.001), fetal weight at birth (p<0.001), number of pregnancies (p=0.023), duration of the latent phase (p<0.001), as well as the difference in the condition of children at birth at the first (p<0.001) and fifth minutes (p<0.001) on the Apgar scale. Risk factors were identified using an adequate logistic regression model. There are three main risk factors for newborns’ mortality in case of hypertension disorders:1) mother’s age (HS=1.25; 95% CI 1.04–1.51 per year); 2) hyperhomocysteinemia (VH 36.3; 95% CI 3; 4–386.7); 3) premature infant (VS 95; 95% CI 3–2900); 4) increased spontaneous oxidation of protein (HS 1.65; 95% CI 1.8–457.5).
Conclusions. Perinatal mortality of pregnant women with hypertension depends on gestational age and fetal weight at birth. The risk factors for newborns’s mortality and the data that must be taken into account for management of pregnancy and childbirth for women with hypertension (maternal age, conditions requiring the appointment of hypohomocystein therapy).