ANTICONVULSIVE ACTION OF THE NEW XYLARATE GERMANIUM COMPLEX (IV) WITH POTASSIUM AT MODELS OF THE ACUTE SEIZURE SYNDROME

The purpose of our work was an estimation of anticonvulsive activity of new complexes of xygerm-3 under the conditions of the different models of acute seizure activity. It is discovered that bis(µ-xylarato)dihydrogermanate (IV) with potassium (xygerm-3) has diminished frequency of origin and intensity of the seizure syndrome under these conditions and has increased duration of the latent period of the first seizures (as compared to drug-references carbamazepin, valproic acid and diazepam), the manifestation of which depends on a dose.