Abstract:
The aim of the study was to analyze changes in erythrocyte diphosphoglycerate levels
and Willebrand factor in the development of hypoxia and endothelial dysfunction in
experimental diabetic retinopathy. The study was performed on white Wistar rats weighing
180-200 g. Our results indicate the development of hypoxia on the 30th day of development of
experimental diabetic retinopathy with subsequent progression of pathological changes on the
60th and 180th day of the study, as evidenced by the decrease level of 2,3 diphosphoglycerate
of erythrocytes in the 2nd group (p <0,001). The most pronounced increase in the studied marker of hypoxia was detected in the 3rd stage of the experiment (p <0,001). As a result of
our study, a violation of the structural and functional state of the endothelium in experimental
diabetic retinopathy was proved, as evidenced by an increase in the level of Willeband factor
in group 2 (p <0.001), most pronounced in stage 3. The most pronounced increase in the level
of Willebrand factor was detected in the 3rd stage of the experiment (p <0.001). Analyzing the
data obtained, we can say that there is a relationship between the development of hypoxia and
endothelial dysfunction in the pathogenesis of experimental diabetic retinopathy.
