Изучались особенности гомеостатических смещений в пожилом возрасте под влиянием фиксированных кардиологических препаратов как при сочетанной, так и при изолированной кардиальной патологии. В каждой из исследуемых групп выявлены и охарактеризованы метаболические трансформации и их динамика во время проведения фармакотерапии двумя комбинациями препаратов с помощью метода лазерной корреляционной спектроскопии. Определены изменения субфракционного состава плазмы крови при использовании профильного фиксированного лечения у пациентов с вышеуказанной патологией.
Сhoice of effective and safe pharmacotherapy in the elderly patients with comorbid cardiac pathology
is not easy. Despite a lot of laboratory and instrumental diagnostic methods monitoring of homeostatic
condition is unsatisfactory, evaluation of the treatment influence is not studied enough and efficacy
of the pharmacotherapy still remains low. In this investigation homeostatic alterations in elder age under the influence of specific pharmacotherapy
in comorbid and isolated cardiac pathology were studied. For this reason 120 elderly patients
were examined and treated according to the medical recommendations approved in Ukraine. According
to the received treatment they were divided into 2 groups: the first group was given lisinopril +
bisoprolol + cardiomagnil. The second group was prescribed lisinopril + bisoprolol + indapamide +
cardiomagnil. The quantity of the patients in each group was 60. According to the diagnosed pathology
the patients were divided into 3 groups: patients with ischemic heart disease (IHD) and primary
hypertension (PH) II stage (1 st group), patients with IHD + PH III (2nd group) and those ones with
isolated IHD (3rd group). The special research method was laser correlation spectrometry. The blood
serum was taken before the treatment and on the 10th day. In each followed-up group there were
revealed and characterized metabolic transformations and their dynamic during the treatment with
two fixed combinations by means of laser correlation spectrometry. Subfractional features of blood
plasma after using profiled therapy in patients with above mentioned pathology were determined.
