Метаболічний статус плазми крові під впливом фіксованої фармакотерапії ізольованої та поєднаної кардіальної патології у пацієнтів літнього віку

Abstract

Изучались особенности гомеостатических смещений в пожилом возрасте под влиянием фиксированных кардиологических препаратов как при сочетанной, так и при изолированной кардиальной патологии. В каждой из исследуемых групп выявлены и охарактеризованы метаболические трансформации и их динамика во время проведения фармакотерапии двумя комбинациями препаратов с помощью метода лазерной корреляционной спектроскопии. Определены изменения субфракционного состава плазмы крови при использовании профильного фиксированного лечения у пациентов с вышеуказанной патологией.

Сhoice of effective and safe pharmacotherapy in the elderly patients with comorbid cardiac pathology is not easy. Despite a lot of laboratory and instrumental diagnostic methods monitoring of homeostatic condition is unsatisfactory, evaluation of the treatment influence is not studied enough and efficacy of the pharmacotherapy still remains low. In this investigation homeostatic alterations in elder age under the influence of specific pharmacotherapy in comorbid and isolated cardiac pathology were studied. For this reason 120 elderly patients were examined and treated according to the medical recommendations approved in Ukraine. According to the received treatment they were divided into 2 groups: the first group was given lisinopril + bisoprolol + cardiomagnil. The second group was prescribed lisinopril + bisoprolol + indapamide + cardiomagnil. The quantity of the patients in each group was 60. According to the diagnosed pathology the patients were divided into 3 groups: patients with ischemic heart disease (IHD) and primary hypertension (PH) II stage (1 st group), patients with IHD + PH III (2nd group) and those ones with isolated IHD (3rd group). The special research method was laser correlation spectrometry. The blood serum was taken before the treatment and on the 10th day. In each followed-up group there were revealed and characterized metabolic transformations and their dynamic during the treatment with two fixed combinations by means of laser correlation spectrometry. Subfractional features of blood plasma after using profiled therapy in patients with above mentioned pathology were determined.