Abstract:
Urinary tract infection (UTI) in children is characterized by a variety of clinical manifestations. A potential cause of different phenotypic responses is a genetically heterogeneous immune response. In view of the central role of interleukin-8 (IL-8) in the
pathogenesis of UTI, the IL-8 gene polymorphism may be an important factor in determining the UTI phenotype. The objective was to study the frequency of polymorphic variants of the gene encoding IL-8 in children with UTI and the impact of polymorphism of IL-8 on the pathology.
