Abstract:
Earlier on the model of pentylenetetrazol (PTZ) –
induced kindling it was shown that blockade of PPARγ with bisphenol A
diglycidyl ether (2,2’-[(1-methylethylidene) bis(4,1-
phenyleneoxymethylene)] bis-oxirane (BADGE) abolished the antiseizure
effects of cerebellar transcranial direct current stimulation (tDCS) performed
with the cathode (Godlevsky L.et al., 2017). Furthermore, PPARγ agonist
pioglitazone caused the suppression of epileptiform activity on both acute
and chronic models of epilepsy. Meanwhile, combined effects of cerebellar
tDCS and PPARγ agonists have not been investigated yet.
Objective: The investigation aimed to determine characteristics of
seizure dynamic in rats with PTZ-induced kindling under conditions of
cerebellar tDCS performed after pioglitazone administration.
